HydroTretRx
Hydrating Tretinoin-Powered Treatment
30-day supply • HSA | FSA-eligible
Lock in a healthy glow with HydroTretᴿˣ, designed to be our most hydrating tretinoin formula to keep your skin looking its healthiest.
Made with a personalized blend of powerful tretinoin and hydrating dexpanthenol (also known as provitamin B5), this formula helps reinforce your skin barrier to keep essential hydration in while helping to boost collagen production for smoother, healthy-looking skin.
Beyond hydration benefits, its active ingredients help promote clearer skin by visibly fading dark spots and preventing future breakouts—so you can stay glowing today and tomorrow.
Important safety information
Made to treat:
Ready to target acne or rosacea? Check out Custom FormulaRx

Ready to target acne or rosacea? Check out Custom FormulaRx









Jennifer Kolinski, NP-C
Pr
Curology provider
A trusted expert who designs a treatment plan for your unique skin and goals
We can prescribe 3 custom-strength ingredients in 1 formula for your skin.

- Fine lines
“Tretinoin is well-known for reducing fine lines, evening out skin tone, and enhancing the skin's overall appearance.”
-Nancy Satur, MD
“Tretinoin is well-known for reducing fine lines, evening out skin tone, and enhancing the skin's overall appearance.”
-Nancy Satur, MD

- Dark spots
“Azelaic acid is a gentle exfoliant that can help patients achieve a smoother skin texture.”
-Nancy Satur, MD
“Azelaic acid is a gentle exfoliant that can help patients achieve a smoother skin texture.”
-Nancy Satur, MD

- Hydration
“I love dexpanthenol because it helps with wound healing and also helps soothe skin irritation."
-Nancy Satur, MD
“I love dexpanthenol because it helps with wound healing and also helps soothe skin irritation."
-Nancy Satur, MD

Check out all potential active ingredients
Ingredients subject to consultation.

Help hydrate while you fight early signs of aging*




Mu
I am satisfied with my journey.




Vivian
It changed my skin.




Courtney
My skin is nearly perfect thanks to Curology!




Trevor
My skin has gotten much clearer and smoother.




Melissa
I saw results in the first 2 weeks and was hooked from there. Not sure I’ll ever be without my Curology products.




Annie
It helps with my acne, and it helps with the dryness that tretinoin typically causes.




Marian
It has improved my skin drastically and helped get rid of the painful cysts I used to get.




Emily
Things are starting to clear up!




Audra
[I] switched to the HydroTretᴿˣ, and now that has been working great for me!




Sheri
My skin became smoother with a noticeable glow that made my skin look less tired.
Designed to be our most hydrating tretinoin formula*
Renew and hydrate with HydroTretᴿˣ.

How it works
- 1
Tell us about you
Begin your consultation by answering quick questions about your skin, goals, and medical history—plus sharing photos.
Begin your consultation by answering quick questions about your skin, goals, and medical history—plus sharing photos.
- 2
Connect with your provider
Get matched with a dermatology provider who reviews your info and photos to prescribe a personalized formula for your skin.
Get matched with a dermatology provider who reviews your info and photos to prescribe a personalized formula for your skin.
- 3
Start your routine
Follow your prescribed treatment plan and see how your skin transforms. Plus, shop non-Rx products for your new routine anytime.
Follow your prescribed treatment plan and see how your skin transforms. Plus, shop non-Rx products for your new routine anytime.
- 4
Get ongoing support
Message your provider anytime with your skin questions. They can adjust your ingredients or prescribe a new Rx formula as your goals change.
Message your provider anytime with your skin questions. They can adjust your ingredients or prescribe a new Rx formula as your goals change.
FAQs
What ingredients are in HydroTretᴿˣ?
A licensed dermatology provider selects 3 active ingredients at the right strength for your skin.
Potential active ingredients include:
Tretinoin
Dexpanthenol (aka provitamin B5)
Niacinamide
Azelaic acid
Inactive ingredients: Aloe Barbadensis Leaf Juice, C13-14 Isoparaffin, Caprylic/Capric Triglyceride, Deionized Water, Laureth-7, Phenoxyethanol, Polyacrylamide, Tocopheryl Acetate, Triethylene Glycol.
All formulas containing tretinoin also contain the antioxidant butylated hydroxytoluene (BHT), and formulas containing both niacinamide and azelaic acid may also contain propylene glycol. All formulas containing dexpanthenol also contain propylene glycol.
How do you use HydroTretᴿˣ?
Our licensed dermatology providers generally advise that after cleansing with Hydro+ Foaming Gel Cleanser, apply a thin layer of HydroTretᴿˣ to your entire face and neck before bed. Leave on overnight. As always, follow your provider’s instructions for your unique skin.
Who is HydroTretᴿˣ for?
HydroTretᴿˣ is designed for dry, sensitive skin. It may be suitable if you want to add tretinoin into your routine but haven’t been able due to concerns around dryness and irritation. Curology also offers a tretinoin-free HydroTretᴿˣ if that is a better option for your unique skin.
Yes, HydroTretᴿˣ can be used by all skin types (dry, combination, oily, and sensitive). Check with your Curology dermatology provider to see if HydroTretᴿˣ is a good option for your skin.
Your Curology dermatology provider can prescribe you a formula containing up to 3 active ingredients, based on your skin quiz, photos, and consultation. Your formula will target your specific skin concerns and can evolve with you over time!
You may be able to use your HSA or FSA pre-tax dollars for this Curology product, plus some of our other acne treatments and sunscreens. Check with your plan’s administrator to confirm eligibility. Restrictions apply.
After your 30-day free trial, you can update your payment method to your HSA or FSA card via your account dashboard. Or you can use a credit or debit card and submit a claim for reimbursement—just download your itemized receipt for your order from your account dashboard.