The minimalist upgrade: why this custom prescription acne treatment + blurring primer is the ultimate AM power move

Are you still choosing between covering your skin or caring for it?

Most treatments focus only on clearing acne, and most primers focus on cosmetic finish. DayPrime Rx changes the game by offering a dual-action formula: a blurring primer base that instantly improves the appearance of skin and a personalized prescription treatment that targets your skin goals with clinically proven active ingredients. 

Depending on your skin goals, your Curology formula can include clinically proven ingredients such as:

• Azelaic acid: Gently exfoliates to help unclog pores, smooth texture, and brighten skin

• Clindamycin: Fights acne-contributing bacteria and soothes inflammation

• Dexpanthenol: Attracts and retains water while helping to boost elasticity

• Niacinamide: Soothes inflammation, helps visibly fade dark spots, and fights free radicals

• Salicylic acid: Goes deep into pores to clear away dead skin cells and excess oil

• Zinc pyrithione: Soothes inflammation and helps keep bacteria and fungi in check

Why choose a prescription primer over OTC or cosmetic solutions?

Over-the-counter (OTC) products are typically designed to be used by a range of skin types and usually contain 1 active ingredient to target concerns like acne. You may need multiple products to cover all of your skin concerns. Prescription skincare at Curology is designed to be targeted and personalized. Our multitasking formulas combine up to 3 clinically proven active ingredients into one convenient bottle to target several concerns at once, such as acne, dark spots, and skin texture. Some of these ingredients, and the care from a licensed provider that comes with them, you simply can’t buy off the shelf.

Some benefits you get by going the prescription route:

• Multitasking Treatments: Your formula can combine up to three clinically proven active ingredients in one bottle to target multiple concerns simultaneously.

• Professional Oversight: A licensed dermatology provider selects ingredients based on your unique skin goals, offering medical authority you cannot find off the shelf.

• Measured Outcomes: Instead of "miracle" promises, this protocol uses researched and tested ingredients to deliver results that build over time.

Clinical Note: Results vary. Rx formulas are prescribed by licensed providers based on your skin concerns and medical history. Most individuals begin to see changes in acne, texture, and tone within 4–8 weeks of consistent daily use. Always follow your provider's specific instructions.

How does the blurring base work with makeup?

The primer base is designed to minimize the look of pores and even out the appearance of texture without clogging pores.

• The "Your Skin, But Smoother" Finish: On natural skin days, it provides a soft-focus effect.

• The Makeup Base: It creates an ideal surface for silicone-based foundations.

• The Application Flex: For the best results, pat, don't rub. A gentle press helps the primer sit evenly and reduces the chance of pilling.

The science behind a smoother morning

Let’s talk about the blurring primer base, because this part is intentionally engineered—not just a makeup trick.

The DayPrime Rx base is formulated to visibly blur imperfections, minimize the look of pores, and even out texture without clogging pores while your active ingredients get to work for clearer-looking skin in the days ahead.

What you see:

• Smoother finish

• Blurred pores

• Softer texture

• More even look under sunscreen or makeup

What your skin gets:

• Active treatment all day

• Ingredients that help address clogged pores

• Oil-balancing support

• Fewer breakouts over time

In other words, cosmetic finish meets clinical function, at the same moment in your day.

How do I integrate DayPrime Rx into my routine?

The best skincare routine is the one you’ll actually stick with—and for most people, the morning is the most predictable part of the day. That makes daytime a prime opportunity for treatment, especially for acne-prone or oily skin.

DayPrimeᴿˣ is built to slide into your existing routine without friction:

Your ideal AM routine with DayPrime Rx

1. Cleanse: Start with a fresh base.

2. Moisturize: Hydrate the skin. 

3. Apply: Pat a thin layer of DayPrime Rx and let it fully dry. (Since this is a prescription product, always follow your Licensed Dermatology Provider’s instructions for how to best use it with your unique skin.)

4. Protect: Always follow with sunscreen.

Pair: During your PM routine, use your nighttime formula (like Custom Formula Rx) for 24-hour treatment support

Teamwork: DayPrime Rx + nighttime treatment

DayPrime Rx can be used alone in the morning, or you can pair it with your nighttime Curology formula—like Custom Formula Rx or HydroTret Rx—for around-the-clock support.

Think of it this way:

• DayPrime Rx: Can be formulated to target acne, texture, tone, oiliness, and clogged pores—all while giving an immediate visible blurring effect.

• Curology’s Custom Formula Rx or HydroTret Rx: Depending on your needs, your provider will prescribe a formula customized for you that can include ingredients such as tretinoin to promote skin cell turnover, boost collagen production, and help prevent new breakouts. Ingredients like tretinoin are best used at night. 

Together, they create a balanced routine that is designed to not overload your skin—just support it, strategically, all day and night.

Who is DayPrime Rx for?

DayPrime Rx can be especially helpful for:

• Acne-prone or breakout-prone skin

• Oily or combination skin

• Visible pores and texture

• Dark spots or post-acne marks

• Rosacea concerns

• Makeup wearers who want a smoother base

• Anyone who wants treatment during the day

FAQ:

Can I use DayPrime Rx if I have sensitive skin?

In general, yes. Because it is personalized, your dermatology provider can choose gentler actives or lower concentrations to help your skin adjust comfortably.

Do I still need my nighttime prescription?

In general, around-the-clock support can be beneficial for many patients; however, it is important to discuss what prescription options may be right for you with your licensed dermatology provider. 

Is this for oily skin only?

No. DayPrime Rx is designed for all skin types, including those with acne-prone skin, visible texture, or rosacea concerns, who want a smoother base for their day.

Written by

Curology Team

Medically reviewed by

Elise Bradley, PA-C