The science behind Curology: dermatologist-trusted prescription ingredients explained

What are the key active ingredients in a Curology custom formula?

Your formula is a treatment prescribed by a licensed provider to target multiple skin concerns with prescription ingredients and personalization that drugstore brands cannot match. Depending on your skin goals (whether you're managing moderate acne or hoping to improve your skin texture), your provider may include:

Tretinoin: The gold standard for cell turnover. It is a vitamin A derivative that helps prevent pores from becoming clogged while supporting smoother-looking skin over time. By normalizing how skin cells shed inside the pore, it addresses a root cause of acne.

Azelaic Acid: A multi-tasking powerhouse that helps keep pores clear, supports a balanced skin tone, and offers anti-inflammatory properties. It is particularly effective at reducing the look of post-acne marks.

Clindamycin: A topical antibiotic that targets acne-contributing bacteria and helps reduce inflammation associated with red, tender breakouts.

Topical Spironolactone: Best for hormonal-pattern acne, particularly along the lower face and jawline. Topical spironolactone helps reduce the effect of androgens (hormones that can increase oil production) at the level of the skin. Supporting a more balanced oil environment within the pore, it can help address one of the contributing factors in acne development.

These ingredients work in a coordinated, multi-targeted approach. While Tretinoin enhances turnover, Azelaic Acid's calming properties complement the process to support an even-looking complexion.

Prescription vs. OTC: Why Rx is the ultimate power move?

In an industry of "hope," certain prescription-strength actives remain the clinical gold standard. Unlike skincare trends that often rely on anecdotal data or "science-lite" marketing, the active ingredients offered in Curology’s prescription formulas are supported by rigorous clinical research.

A subscription with Curology unlocks access to a personalized prescription formula with up to 3x more active ingredients than traditional OTC products. While some trends may complement a routine, evidence-based prescription treatments are designed for predictability, providing receipts rather than just "vibes".

How do I distinguish between a "Tretinoin Purge" and irritation?

It is common for the early adjustment phase of Tretinoin (frequently called "purging") to share similarities with irritation.

• The Purge: As pores clear and cell renewal accelerates, you may experience temporary breakouts, even in areas that weren't previously congested. This is a predictable part of the skin adapting to the treatment.

• Irritation: This typically presents as redness, dryness, stinging, or sensitivity.

Through your Curology account, you have continued access to licensed medical providers who can help clarify what your skin is experiencing. Your provider is just a DM away and happy to help with any questions related to your skin health. If irritation occurs, your provider can discuss appropriate next steps, ensuring you stay on your routine safely.

What is the clinical rationale for formula adjustments?

Skincare is a science, not a static product. Your formula should evolve because your skin does, influenced by seasons, hormones, or your response to the initial strength.

Formula adjustments are guided by an ongoing partnership between the patient and their provider. Dermatology providers consider several factors to determine if an adjustment is necessary. They review your progress photos, current medical history, and skincare goals to assess how your skin is changing. Your provider will also evaluate common factors that may affect results, like product tolerance or routine consistency. From there, a provider may adjust the prescription, recommend complementary over-the-counter products, or explore other treatment options as appropriate—all with the goal of supporting the patient’s evolving skin needs and continuing to deliver measured outcomes.

More than just a routine

Traditional dermatology appointments often rely on annual office visits or are often scheduled months apart, making it difficult to address concerns in real-time. Think of Curology’s model as a Clinical Concierge that gives you:

1. Continuous Care: Ongoing messaging allows for more responsive care than what is typically possible with a traditional office visit.

2. Visual Receipts: Providers look for a combination of visible changes, such as the overall pattern and distribution of breakouts, whether inflamed lesions appear to be calming, and how the skin’s texture and tone are evolving, to monitor progress and make adjustments if needed.

3. Minimalist Routine: We advocate for a streamlined "less is more" approach, cutting the noise of 10-step routines to help improve adherence and promote consistency.

Instead of a routine that feels like a chore, personalized formulas are made to fit seamlessly into daily life, designed to provide progress you can actually measure.

Rx products are subject to medical consultation. Results may vary. Restrictions apply. 

Written by

Brent Selders, PA-C

Medically reviewed by

Elise Bradley, PA-C